THREE CASES OF MYELODYSPLASTIC-MYELOPROLIFERATIVE DISORDER WITH ABNORMAL CHROMATIN CLUMPING IN GRANULOCYTES

The syndrome of abnormal chromatin clumping in leukocytes.

A65-year-old female was admitted to our Institute for anemia-related symptoms. The hematological findings were as follows: Hb 65 g/L, platelet count 45310/L; WBC 18310/L with neutrophils 74%, lymphocytes 8%; monocytes 2%, promyelocytes 2%, myelocytes 12%, metamyelocytes 2%. When observed under the microscope, neutrophils were characterized by loss of segmentation (pelgeroid features) and abnorm...

Myelodysplastic/myeloproliferative neoplasms.

Myelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are rare de novo myeloid neoplasms that exhibit hybrid dysplastic and proliferative features at presentation. This SHP/EAHP Workshop session was uniquely problematic owing to the overlap between MDS/MPNs and both chronic myeloproliferative neoplasms and myelodysplasia. The borderline between MDS/MPNs and overt acute myeloid leukemias was a...

Myelodysplastic/myeloproliferative neoplasms.

According to the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues, myelodysplastic/myeloproliferative neoplasms are clonal myeloid neoplasms that have some clinical, laboratory, or morphologic findings that support a diagnosis of myelodysplastic syndrome, and other findings that are more consistent with myeloproliferative neoplasms. These disorders ...

Myelodysplastic/myeloproliferative disorders.

Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms.

BACKGROUND Aberrant activation of tyrosine kinases, caused by either mutation or gene fusion, is of major importance for the development of many hematologic malignancies, particularly myeloproliferative neoplasms. We hypothesized that hitherto unrecognized, cytogenetically cryptic tyrosine kinase fusions may be common in non-classical or atypical myeloproliferative neoplasms and related myelody...